Authors: H. Matsushita; T. Kurabayashi; M. Tomita; K. Tanaka

Source: Human Reproduction, Volume 19, Number 1, January 2004 , pp. 59-64(6)

Publisher: Oxford University Press

Abstract:

BACKGROUND: Our aims were to follow the longitudinal changes in lumbar spine bone mineral density (BMD) with multiple pregnancies, and to study whether polymorphisms in the vitamin D receptor (VDR) and estrogen receptor (ER) genes may influence the results. METHODS: We repeatedly measured the BMD of the lumbar spine (L2–L4) of 133 women who had undergone two successive pregnancies and 73 non-pregnant controls, and analysed the restriction fragment length polymorphisms using restriction endonucleases TaqI, ApaI and FokI for the VDR gene, and PvuII and XbaI for the ER gene. RESULTS: Cases and controls had no significant differences in the longitudinal BMD changes. The mean percentage change in lumbar BMD (BMD%) of the women with the XX/Xx genotype was significantly lower than that of the women with the xx genotype after adjusting for age at each delivery, BMD of the first scan, and interval between the scans (0.2 ± 3.3 versus 2.0 ± 4.2%; P = 0.030, analysis of covariance). Multiple regression analyses to evaluate the contribution of the XbaI polymorphism of the ER gene on BMD% showed that the percentage decrease in BMD was greater for women lacking the XbaI restriction site (adjusted R² = 0.188, P < 0.0001). CONCLUSIONS: The present study suggests that the BMD% was significantly influenced by the XbaI polymorphism of the ER gene.

Keywords: bone mineral density/estrogen receptor/genetic pol

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/deh009

Affiliations: 1: To whom correspondence should be addressed. e-mail: takumi@med.niigata-u.ac.jp

Publication date: 2004-01-01

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• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

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