Epigenetic risks related to assisted reproductive technologies: Epigenetics, imprinting, ART and icebergs?
Authors: Maher, Eamonn R.; Afnan, Masoud; Barratt, Christopher L.
Source: Human Reproduction, Volume 18, Number 12, December 2003 , pp. 2508-2511(4)
Publisher: Oxford University Press
Abstract:Recently, a series of case reports and small studies has suggested that births involving assisted reproductive technology (ART) may have an increased risk of imprinting disorders such as Beckwith–Wiedemann syndrome and Angelman syndrome. Herein, the significance and implications of these findings are discussed. It is speculated that, although such imprinting disorders may be shown to be only rare complications of ART, epigenetic errors might account for a much wider spectrum of ART‐related complications than is recognized currently. Addressing these questions should be a priority for research on cohorts of ART children.
Document Type: Research Article
Affiliations: Assisted Conception Unit, Birmingham Women’s Hospital, Edgbaston, Birmingham and Division of Reproductive and Child Health, University of Birmingham Medical School, Birmingham, UK
Publication date: December 2003
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.