Successful myomectomy during pregnancy

Authors: D.E. Lolis; S.N. Kalantaridou; G. Makrydimas; A. Sotiriadis; I. Navrozoglou; K. Zikopoulos; E.A. Paraskevaidis

Source: Human Reproduction, Volume 18, Number 8, August 2003 , pp. 1699-1702(4)

Publisher: Oxford University Press

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Abstract:

BACKGROUND: Although leiomyomas usually remain asymptomatic during pregnancy, they may complicate its course. In this study, pregnancy outcome observed when myomectomy was performed during pregnancy in carefully selected patients is presented. METHODS: A prospective cohort study of 13 women who underwent myomectomy during pregnancy between January 1994 and December 2001. Surgical management of leiomyoma was required on the basis of characteristics of the myoma and symptoms. RESULTS: Among a total of 15 579 women registered at the authors’ prenatal clinic, 622 consecutive pregnant women had sonographically identified myoma; hence, the incidence was 3.9% (95% CI 3.6–4.3%). The vast majority of these women was asymptomatic during pregnancy or managed conservatively (97.4%; 95% CI 96–98%). Among 622 pregnant patients with leiomyoma, 13 presented with complications during pregnancy that required surgical intervention (2.1%; 95% CI 0.9–3.2%), due to increase in lesion size causing discomfort and/or severe abdominal pain not responding to conservative management with analgesic and non-steroidal anti-inflammatory drug medication. In 92% of these cases, successful myomectomy was performed and the pregnancy progressed to term without further complications. CONCLUSIONS: These data provide reassurance for pregnant women with uterine myoma. Surgical management of uterine leiomyoma during pregnancy may be successfully performed in carefully selected patients.

Keywords: leiomyoma/management of leiomyoma/myomectomy/pregn

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/deg318

Affiliations: 1: To whom correspondence should be addressed at: Kosti Palama 3, 45221 Ioannina, Greece. e-mail: kalantas@exchange.nih.gov

Publication date: 2003-08-01

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Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

Successful myomectomy during pregnancy

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