Authors: Noriko Kado; Jo Kitawaki; Hisato Koshiba; Hiroaki Ishihara; Yui Kitaoka; Mariko Teramoto; Hideo Honjo

Source: Human Reproduction, Volume 18, Number 4, April 2003 , pp. 715-720(6)

Publisher: Oxford University Press

Abstract:

BACKGROUND: The aim of this study was to investigate the relationships between the serum levels of soluble leptin receptor (SLEPR), and total, free and bound leptin, and the change in the serum SLEPR level during an IVF cycle. METHODS: Serum concentrations of leptin and SLEPR were measured in 50 Japanese women of reproductive age, and 20 patients participating in an IVF programme. The total leptin was fractionated into free and bound portions by gel filtration chromatography. RESULTS: The SLEPR level was negatively correlated with the body mass index (BMI) (r = –0.548, P < 0.0001), total leptin (r = –0.433, P < 0.0001), the percentage of free leptin (r = –0.732, P < 0.0001) and the absolute free leptin concentration (r = –0.506, P < 0.0001). The SLEPR level was positively correlated with the percentage of bound leptin (r = 0.730, P < 0.0001), whereas there was little variation in the absolute bound leptin concentration, regardless of the BMI or SLEPR concentration. During the IVF cycle, total and free leptin elevated during maximal ovarian stimulation, whereas there was no significant difference in the SLEPR concentration. CONCLUSIONS: The results demonstrate a skilful mechanism where a change in the serum SLEPR level regulates, in part, the biological activity of leptin in the circulation.

Keywords: bound leptin/controlled ovarian hyperstimulation/f

Document Type: Research article

DOI: http://dx.doi.org/10.1093/humrep/deg186

Affiliations: 1: To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602–8566, Japan. e-mail: kitawaki@koto.kpu-m.ac.jp

Publication date: 2003-04-01

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

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