Triple-Y syndrome following ICSI treatment in a couple with normal chromosomes
Authors: Venkataraman, Geetha; Craft, Ian
Source: Human Reproduction, Volume 17, Number 10, October 2002 , pp. 2560-2563(4)
Publisher: Oxford University Press
Abstract:We report the case of 48,XYYY in a fetus resulting from ICSI treatment in a chromosomally normal couple. A 35 year old couple underwent an ICSI treatment resulting in a maintained clinical pregnancy. Amniocentesis at 13 weeks identified the Triple-Y syndrome in the fetus. Both the parents had normal karyotypes (46,XX and 46,XY). The pregnancy was terminated at 18 weeks and fetal tissue culture confirmed the 48,XYYY syndrome. This is the first reported case of the Triple-Y syndrome following ICSI treatment in a chromosomally normal couple.
Document Type: Research Article
Affiliations: London Fertility Centre, Cozens House, 112a Harley Street, London W1G 7JH, UK
Publication date: October 2002
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.