Rescue ICSI of unfertilized oocytes after IVF
Source: Human Reproduction, Volume 17, Number 9, September 2002 , pp. 2423-2427(5)
Publisher: Oxford University Press
Abstract:BACKGROUND: Failed fertilization after IVF occurs in 10–20% of cycles. Conflicting results of rescue fertilization by ICSI have been reported. We therefore compared the success rate in terms of fertilization and pregnancy of cycles in which rescue ICSI was performed with those from a matched control group of primarily ICSI cycles. METHODS: Unfertilized oocytes from IVF cycles with total fertilization failure where at least four metaphase II oocytes were available were treated by ICSI (group I; n = 120). A matched control group was established with patients undergoing ICSI during the same period (group II; n = 280). RESULTS: Both fertilization rate and the proportion of embryos with four blastomeres on day 2 after ICSI were significantly higher in the control group (P < 0.05). Embryo quality, however, was comparable in both groups. The pregnancy rate in the control group was 25.3% whereas in group I with rescue ICSI, no pregnancy was obtained. CONCLUSIONS: Although unfertilized oocytes after IVF can be fertilized by ICSI, the developmental potential of the ensuing embryos is very poor. Therefore, rescue ICSI after total failure of fertilization is not recommended.
Document Type: Research Article
Affiliations: 1: Department of Gynecology and 2: Infertility Center, Department of Obstetrics and Gynecology, Ghent University Hospital, Belgium 3: Cryobank–Infertility Center, Bialystok, Poland and 4: Department of Perinatology, Bialystok Medical University, Sklodowskiej 24A, Bialystok 15–276,
Publication date: September 2002
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.