Myocardial infarction and third generation oral contraceptives: aggregation of recent studies
Source: Human Reproduction, Volume 17, Number 9, September 2002 , pp. 2307-2314(8)
Publisher: Oxford University Press
Abstract:BACKGROUND: Arterial cardiovascular and cerebrovascular adverse events associated with oral contraceptives (OC) are a major concern to the clinician. This paper aggregates the findings of seven recent oral contraceptive studies on the risk of acute myocardial infarction (MI) among users of second (2gen) and third (3gen) generation OC. METHODS: Odds ratios (OR) from seven original studies published between 1996 and 2001 underwent meta-analysis. They had accrued 6464 subjects since 1996. In addition, estimates of 22 studies published from 1965 to 1966 were synthesized using medians and ranges as an historical point of reference. RESULTS: Four meta-analyses were performed for each of the relevant comparisons. The point estimates for 3gen versus 2gen OC ranged from 0.44 (0.24–0.80) to 0.62 (0.38–0.99). Compared with non-users, the aggregated OR for 3gen OC was 1.13 (0.66–1.92); for 2gen OC it was 2.18 (1.62–2.94). CONCLUSIONS: This overview of seven controlled observational studies confirms that 3gen OC do not convey harm in regard to MI compared with non-users of OC. The aggregate data and the continuing replication of findings allow interpretation of benefit compared with older combined OC.
Document Type: Research Article
Affiliations: 1: Emeritus Professor of Epidemiology and 2: Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada and 3: Professor of Medical Statistics, University of Surrey, Guildford, Surrey, UK
Publication date: 2002-09-01
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.