IngentaConnect Metabolic characteristics of women who developed ovarian hypersti...

Authors: Annick Delvigne¹; Karol Kostyla¹; Anne De Leener²; Bernard Lejeune³; Brigitte Cantiniaux¹; Pierre Bergmann⁴; Serge Rozenberg¹

Source: Human Reproduction, Volume 17, Number 8, August 2002 , pp. 1994-1996(3)

Publisher: Oxford University Press

Abstract:

BACKGROUND: The aim of this study was to investigate whether a higher incidence of hyperinsulinism is found in women who have suffered from ovarian hyperstimulation syndrome (OHSS) as compared with other IVF patients. Additionally, we also assessed whether any abnormalities in the haemostatic system were more frequent in women with a past history of OHSS. METHODS: A pilot study was carried out involving OHSS patients and matched IVF patients. Homeostasis model assessment (HOMA) of insulin sensitivity was calculated. The main outcome measures were: insulin sensitivity, coagulation anomalies, factor V Leiden mutations, methylene tetrahydrofolate reductase (MTHFR) polymorphism and prothrombin gene mutation, protein C and protein S deficiency. RESULTS: No increased incidence in hyperinsulism nor in abnormalities of the haemostatic system were observed. CONCLUSIONS: This pilot study does not provide evidence for an increased prevalence of hyperinsulinism among women who have developed OHSS in the past.

Keywords: insulin resistance; IVF; ovarian hyperstimulation syndrome (OHSS)

Document Type: Research article

Affiliations: 1: Departments of Obstetrics and Gynaecology, IVF and Haematology, St Pierre University Hospital, Free University of Brussels, Rue Haute, 322, 1000 Brussels, 2: Department of Medical Genetics and Institute of Interdisciplinary Research, Faculty of Medicine, Free University of Brussels, 1070 Brussels, 3: IVF Center, Institut Médical E. Cavell, Rue Edith Cavell 32, 1080 Brussels and 4: Department of Clinical Chemistry, University Hospital Brugmann, 4 Place Van Gehuchten, Free University of Brussels, 1020 Brussels, Belgium

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Metabolic characteristics of women who developed ovarian hyperstimulation syndrome