The concentration of inhibin B in follicular fluid: relation to oocyte maturation and embryo development

Authors: Chia-Lin Chang; Tzu-Hao Wang; Shang-Gwo Horng; Hsien-Ming Wu; Hsin-Shih Wang; Yung-Kuei Soong

Source: Human Reproduction, Volume 17, Number 7, July 2002 , pp. 1724-1728(5)

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Abstract:

BACKGROUND: The objective of the present study was to investigate the correlation between inhibin B and estradiol levels in follicular fluid (FF) with the quality of subsequent embryo development from in-vitro fertilized oocytes aspirated from the same follicle. METHODS: A total of 156 infertile women undergoing controlled ovarian stimulation for IVF and embryo transfer was recruited to the present study. Prospectively, 233 FF samples and matched mature oocytes were studied. Concentrations of inhibin B and estradiol were determined by enzyme-linked immunosorbent assay (ELISA) and immunofluorometric assay (IFMA) respectively. RESULTS: Inhibin B levels in FF were significantly correlated with embryo scores on days 2 and 3 (48 and 72 h after oocyte retrieval). In contrast, both inhibin B and estradiol levels in FF were inversely related to age. Furthermore, FF inhibin B levels were inversely associated with serum FSH levels on day 3 of the menstrual cycle, which was believed to reflect the ovarian reserve. CONCLUSION: Inhibin B in FF may serve as an effective marker of follicular development and a useful predictor of quality of embryo. In addition, quality of oocyte is age-related and declines as age increases.

Keywords: embryo score; estradiol; granulosa cell; inhibin B; oocyte maturation

Document Type: Research article

Affiliations: 1: Department of Obstetrics and Gynaecology, Chang-Gung Memorial Hospital, Lin-Kou Medical Centre, Taipei, Taiwan, Republic of China

Publication date: 2002-07-01

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Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

The concentration of inhibin B in follicular fluid: relation to oocyte maturation and embryo development

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