Authors: Masato Fujisawa; Takafumi Yamasaki; Hiroshi Okada

Source: Human Reproduction, Volume 17, Number 4, April 2002 , pp. 968-970(3)

Publisher: Oxford University Press

Abstract:

BACKGROUND: The function of anti-Müllerian hormone (AMH) in seminal plasma in adulthood is uncertain. We examined the significance of seminal AMH for spermatogenesis. METHODS: We measured seminal concentrations of AMH in 39 oligozoospermic men (mean age ± SD, 32.7 ± 4.3 years) and 10 normal volunteers to examine the association of seminal AMH with spermatogenesis. The seminal concentrations of AMH in oligozoospermic men (149.3 ± 254.0 pmol/l) were significantly lower than in normal men (249.0 ± 167.7 pmol/l; P ± 0.0337). Seminal AMH concentration correlated significantly with sperm concentration (r = 0.339, P = 0.0350) and mean testicular volume (r = 0.440, P = 0.246). The serum concentration of LH (r = – 0.365, P = 0.0241), but not FSH, testosterone or estradiol, correlated significantly with AMH concentration in seminal plasma. CONCLUSIONS: AMH in seminal plasma may be important for sperm production, and is a good marker for Sertoli cell development.

Keywords: anti-Müllerian hormone; oligozoospermia; Sertoli cell development; spermatogenesis

Document Type: Research article

Affiliations: 1: Division of Urology, Department of Organ Therapeutics, Kobe University Graduate School of Medicine, Kobe, Japan

Publication date: 2002-04-01

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

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