Reproductive epidemiology. Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities
Authors: Slama, R.1; Eustache, F.2; Ducot, B.1; Jensen, T.K.3; Jørgensen, N.3; Horte, A.4; Irvine, S.5; Suominen, J.4; Andersen, A.G.3; Auger, J.2; Vierula, M.4; Toppari, J.4; Andersen, A.N.6; Keiding, N.7; Skakkebæk, N.E.3; Spira, A.1
Source: Human Reproduction, Volume 17, Number 2, February 2002 , pp. 503-515(13)
Publisher: Oxford University Press
Abstract:BACKGROUND: In fertile populations, little is known about the association between semen parameters and time to pregnancy (TTP). METHODS: Pregnant women from Copenhagen, Edinburgh, Paris and Turku who conceived without medical intervention were asked for their TTP (942 couples), and their partners provided a semen sample. The proportion of morphologically normal sperm and the multiple anomalies index (MAI, ratio of the total number of anomalies to the number of abnormal sperm) were centrally estimated. We estimated rate ratios for the occurrence of a pregnancy by a discrete survival model, adjusted for sexual activity and female factors affecting fecundity. RESULTS: Increasing sperm concentration influenced TTP up to 55×106/ml. The proportion of morphologically normal sperm influenced TTP up to 39% according to David's criteria, and this association held among the subjects with a sperm concentration >55×106/ml. For strict criteria, the threshold value was 19% normal sperm. An increase of 0.5 in MAI was associated with an adjusted rate ratio for the occurrence of a pregnancy of 0.68 (95% confidence interval: 0.54–0.85). CONCLUSIONS: These results highlight the importance of sperm morphology parameters and indicate that the effect of proportion of normal sperm on TTP may be independent of sperm concentration.
Document Type: Research Article
Affiliations: 1: INSERM U292, Research in Public Health, 82 rue du Général Leclerc, 94276 Le Kremlin-Bicêtre cedex, France, 2: Service de Biologie de la Reproduction, Université Paris V, Groupe Hospitalier Cochin, 123 Boulevard de Port-Royal, FR-75014 Paris, France, 3: Department of Growth and Reproduction, Rigshospitalet, The Juliane Marie Centre, Section GR-5064, Blegdamsvej 9, DK-2100 Copenhagen, Denmark, 4: Anatomy, 5: MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9ET, UK, 6: The Fertility Clinic, Rigshospitalet, The Juliane Marie Centre, Section 4071, Blegdamsvej 9, DK-2100 Copenhagen, and 7: Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
Publication date: 2002-02-01
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.
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- In this Subject: Anatomy & Physiology , Obstetrics & Gynecology
- By this author: Slama, R. ; Eustache, F. ; Ducot, B. ; Jensen, T.K. ; Jørgensen, N. ; Horte, A. ; Irvine, S. ; Suominen, J. ; Andersen, A.G. ; Auger, J. ; Vierula, M. ; Toppari, J. ; Andersen, A.N. ; Keiding, N. ; Skakkebæk, N.E. ; Spira, A.