Infertility. Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study
Authors: Janssens, R.M.J.; Lambalk, C.B.; Vermeiden, J.P.W.; Schats, R.; Bernards, J.M.; Rekers-Mombarg, L.T.M.
Source: Human Reproduction, Volume 15, Number 11, November 2000 , pp. 2333-2340(8)
Publisher: Oxford University Press
Abstract:Gonadotrophin-releasing hormone agonists (GnRHa) are routinely used in IVF programmes to prevent an unwanted LH surge and consequent ovulation. Despite its widespread use in IVF, a convincing dose recommendation for GnRHa in IVF does not exist. In our opinion, the lowest possible dose of GnRHa should be used. Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol. A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 g daily. Ovarian stimulation was performed with two or three ampoules of FSH daily. A premature LH surge occurred in 23% of placebo-treated patients, but in none of the triptorelin acetate-treated patients. There were significantly more oocytes and embryos in the 50 and 100 g triptorelin groups. There was no dose relationship in rates of either implantation, pregnancy, ongoing pregnancy, live birth or baby take-home. In this study we showed that daily administration of 15 g triptorelin is sufficient to prevent a premature LH surge, and that 50 g is equivalent to 100 g in terms of IVF results.
Document Type: Research Article
Publication date: 2000-11-01
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