Authors: Maija Tulppala; Milla Aho; Timo Tuuri; Sirpa Vilska; Tuija Foudila; Tiina Hakala-Ala-Pietilä; Jarna Moilanen; Tarja Bützow; Seija Kaukoranta; Viveca Söderström-Anttila; Rita Siegberg; Anne-Maria Suikkari

Source: Human Reproduction, Volume 14, Number 11, November 1999 , pp. 2709-2715(7)

Publisher: Oxford University Press

Abstract:

A randomized comparison of two recombinant human follicle-stimulating hormone (recFSH) preparations (Gonal-F^® and Puregon^®) in ovarian stimulation for in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) was carried out at the Infertility Clinic of the Family Federation of Finland. A total of 348 women (aged 22–43 years) suffering from infertility due to miscellaneous causes was recruited. Of these, 344 underwent stimulation using equal starting doses (150 IU/day: Gonal-F^® n = 164, Puregon^® n = 158 or 300 IU/day: Gonal-F^® n = 8, Puregon^® n = 14) after down-regulation with intranasal buserelin from the mid-luteal phase. Similar clinical pregnancy rates were achieved with both preparations; 33.5% per cycle and 37.4% per embryo transfer (24.5% one-embryo and 75.5% two-embryo transfers, n = 147) with Gonal-F^® (150 IU/day) and 32.9% per cycle and 36.4% per embryo transfer (30.1% one-embryo and 69.9% two-embryo transfers, n = 145) with Puregon^® (150 IU/day). The ongoing cumulative pregnancy rates after frozen–thawed embryo transfer were 35.4% with Gonal-F^® and 37.7% with Puregon^®. Six cycles were cancelled because of a low response (three in each group). Similar numbers of oocytes were obtained in both groups; 13.0 with 150 IU/day and 6.1 with 300 IU/day Gonal-F^®, and 12.4 with 150 IU/day and 7.1 with 300 IU/day Puregon^®. The fertilization and cleavage rates and the incidence of moderate or severe ovarian hyperstimulation syndrome (Gonal-F^®, 2.0% and Puregon^®, 0.7%) were also similar. Gonal-F^® and Puregon^® were equally and highly effective in stimulation for IVF and ICSI.

Keywords: embryo transfer; follicle-stimulating hormone; in-vitro fertilization; intracytoplasmic sperm injection; pregnancy rate

Document Type: Research article

Affiliations: 1: Infertility Clinic, The Family Federation of Finland, Kalevankatu 16, FIN-00100 Helsinki and

Publication date: 1999-11-01

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

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• In this Subject: Anatomy & Physiology ,  Obstetrics & Gynecology
• By this author: Maija Tulppala ;  Milla Aho ;  Timo Tuuri ;  Sirpa Vilska ;  Tuija Foudila ;  Tiina Hakala-Ala-Pietilä ;  Jarna Moilanen ;  Tarja Bützow ;  Seija Kaukoranta ;  Viveca Söderström-Anttila ;  Rita Siegberg ;  Anne-Maria Suikkari

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