Subfertile men with constitutive chromosome abnormalities do not necessarily refrain from intracytoplasmic sperm injection treatment: a follow-up study on 75 Dutch patients
Authors: Giltay, JC1; Kastrop, PMM2; Tuerlings, JHAM3; Kremer, JAM3; Tiemessen, CHJ4; Gerssen-Schoorl, KBJ5; van der Veen, F6; de Vries, J6; Hordijk, R7; Hamers, GJH8; Hansson, K9; van der Blij-Philipsen, M10; Govaerts, LCP11; Pieters, MHEC1; Madan, K12; Scheres, JMJC1
Source: Human Reproduction, Volume 14, Number 2, February 1999 , pp. 318-320(3)
Publisher: Oxford University Press
Abstract:A follow-up study was performed to investigate the impact of the detection of a chromosome abnormality in infertile men who are candidates for intracytoplasmic sperm injection (ICSI) treatment. In this collaborative study between clinical genetics centres and fertility clinics in the Netherlands, 75 ICSI couples of which the male partners had a chromosome abnormality were included. All couples were extensively counselled on the risk of having a chromosomally unbalanced child. Forty-two out of 75 couples chose to proceed with the ICSI treatment. So far, treatment has resulted in a pregnancy in 11 cases. Four of them opted to have invasive prenatal diagnosis. Despite the genetic risks related to a chromosome abnormality in infertile men, a small majority (56%) of the couples did not refrain from the ICSI treatment.
Keywords:chromosome abnormality/follow-up/intracytoplasmic sperm injection (ICSI)/male infertility/oligoasthenoteratozoospermia
Document Type: Research Article
Affiliations: 1: Clinical Genetics Center Utrecht, The Netherlands 2: University Hospital Utrecht, The Netherlnds 3: University Hospital Nijmegen, The Netherlands 4: Elisabeth Hospital, Tilburg, The Netherlands 5: Streeklaboratorium Enschede, 6: Academic Medical Center, Amsterdam, The Netherlands 7: University of Groningen, 8: University of Maastricht, The Netherlands 9: University Hospital Leiden, The Netherlands 10: St. Erfelijkheidsonderzoek Noord Brabant, Veldhoven, The Netherlands 11: University Hospital Dijkzigt, Rotterdam and 12: University Hospital, Vrije Universiteit, Amsterdam, The Netherlands
Publication date: 1999-02-01
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.
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- In this Subject: Anatomy & Physiology , Obstetrics & Gynecology
- By this author: Giltay, JC ; Kastrop, PMM ; Tuerlings, JHAM ; Kremer, JAM ; Tiemessen, CHJ ; Gerssen-Schoorl, KBJ ; van der Veen, F ; de Vries, J ; Hordijk, R ; Hamers, GJH ; Hansson, K ; van der Blij-Philipsen, M ; Govaerts, LCP ; Pieters, MHEC ; Madan, K ; Scheres, JMJC