Authors: TC Li¹; PG Spring¹; C Bygrave²; SM Laird¹; E Serle¹; M Spuijbroek¹; O Adekanmi¹

Source: Human Reproduction, Volume 13, Number 12, December 1998 , pp. 3525-3529(5)

Publisher: Oxford University Press

Abstract:

In this study, the potential prognostic value of serial ultrasonographic, endocrinological and biochemical measurements in the early pregnancy of women with a history of unexplained recurrent miscarriage was examined. A total of 113 pregnancies among 93 women were studied, of which 77 (68%) resulted in live birth, whereas 36 (32%) ended in a miscarriage. The normal range (5-95th centile) of various measurements was derived from pregnancies which resulted in a live birth. Among the 36 failed pregnancies, 42% had one or more human chorionic gonadotrophin (HCG) measurements, 35% had one or more gestation-sac diameter measurements, 33% had one or more embryonic heart rate measurements, 20% had one or more crown-rump length measurements and 9% had one or more placental protein 14 measurements below the normal range, a week or more prior to the confirmation of miscarriage. Altogether, 22/36 = 61% of the failed pregnancies could have been predicted on the basis of one or more of the measurements below the normal range.

Keywords: -human chorionic gonadotrophin/miscarriage/placental protein 14/pregnancy outcome/ultrasound

Document Type: Research article

Affiliations: 1: Biomedical Research Unit, Jessop Hospital for Women, 2: Department of Medical Physics and Clinical Engineering, Royal Hallamshire Hospital, Sheffield, UK

Publication date: 1998-12-01

More about this publication?

• Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.

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