Exogenous influences on human fertility: fluctuations in sperm parameters and results of in-vitro fertilization coincide with conceptions in the normal population
Author: Ossenbühn, S
Source: Human Reproduction, Volume 13, Number 8, August 1998 , pp. 2165-2171(7)
Publisher: Oxford University Press
Abstract:Intra- and interindividual short-term fluctuations of sperm parameters were observed in assisted reproduction patients, paralleled by respective fluctuations of the in-vitro fertilization (IVF) results. To test whether the fertility fluctuations observed in the clinic were representative for the overall population, birth statistics of two normal subpopulations (urban and rural) were studied. There were highly significant parallels in the fluctuations of the monthly deliveries in both normal and subpopulations. Also, there was a significant correlation when the fluctuation of sperm parameters in IVF patients was compared with those of a control group. Furthermore, delivery fluctuations in the overall population were significantly paralleled by fluctuations in sperm parameters and IVF results around the conception time of these deliveries. In all groups, the pattern and amplitude of the short-term fluctuations varied from year to year. Frequently observed peaks in late autumn gave rise to the appearance of a semi-seasonal variation in fertility. The existence of an external influence on overall male gamete quality must be postulated, which has considerable influence on the IVF results. This short-term influence might be causally linked to the factors responsible for the previously found annual variation in human fertility and possibly for the long-term changes in human reproductive function.
Keywords:fertility fluctuation/IVF results/normal population/seasonality/sperm parameters
Document Type: Research Article
Publication date: 1998-08-01
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.