Low dose of cyproterone acetate and testosterone enanthate for contraception in men
Source: Human Reproduction, Volume 13, Number 5, May 1998 , pp. 1225-1229(5)
Publisher: Oxford University Press
Abstract:After a control phase, 10 normal men received cyproterone acetate (CPA) at a dose of 25 mg/day (CPA-25; n = 5) or 12.5 mg/day (CPA-12.5; n = 5) plus testosterone enanthate (TE) 100 mg/week, for 16 weeks. Throughout the study sperm counts were performed every 2 weeks, and luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, biochemical and haematological tests were performed every 4 weeks. All five men in group CPA-25 and three men in group CPA-12.5 achieved azoospermia. One man in group CPA-25 was azoospermic by week 12 of hormone administration, but had a sperm count of 0.1 x 106/ml at week 16. Time to azoospermia was 9.0 ± 1.3 and 8.7 ± 0.7 weeks in groups CPA-25 and CPA-12.5 respectively. Gonadotrophins were decreased by week 4 of hormone administration, remained around the minimum detectability of the assay for the duration of hormone administration and returned to baseline after stopping hormone administration. Testosterone values did not change. No change in any biochemical parameters was found. Haematological parameters were decreased at week 16 of hormone administration and returned to baseline after stopping hormone administration. In conclusion, these results suggest than an hormonal regimen consisting of testosterone plus a progestin with anti-androgenic properties holds promise as an effective, safe and reversible male contraceptive.
Keywords: contraception/cyproterone acetate/gonadotrophins/spermatogenesis/testosterone
Document Type: Research Article
Affiliations: 1: Department of Obstetrics and Gynecology and Core Lab, S. Orsola Hospital, University of Bologna, Italy 2: Department of Veterans Affairs, Puget Sound Health Care System, Population Center for Research in Reproduction and Department of Medicine, University of Washington, Seattle, WA, USA
Publication date: 1998-05-01
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.