Immunomodulation by human seminal plasma: a benefit for spermatozoon and pathogen?
Authors: Kelly, R W; Critchley, H O
Source: Human Reproduction, Volume 12, Number 10, October 1997 , pp. 2200-2207(8)
Publisher: Oxford University Press
Abstract:The immunosuppressive effect of human seminal plasma and its implications for sperm survival are reviewed. Human semen contains high concentrations of prostaglandins that can effect a cytokine-mediated switch away from a cell-mediated immune response. This effect on antigen presenting cells would induce a state of non-responsiveness to sperm antigens in the female reproductive tract. It is postulated that the induction of anergy to sperm antigen may be fundamental to the continuing fecundity of the individual. However, although this immune system modulation will benefit the spermatozoa, the response to infective agents present in semen will also be affected, which may play a critical role in the aetiology and progress of sexually transmitted disease.
Document Type: Journal Article
Publication date: October 1997
- Human Reproduction features full-length, peer-reviewed papers reporting original research, clinical case histories, as well as opinions and debates on topical issues. Papers published cover the scientific and medical aspects of reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues. The highest scientific and editorial standard is maintained throughout the journal along with a rapid rate of publication.