IngentaConnect Genome-wide variation in recombination in female meiosis: a risk ...

Authors: Brown, Amanda Savage; Feingold, Eleanor¹; Broman, Karl W.²; Sherman, Stephanie L.

Source: Human Molecular Genetics, Volume 9, Number 4, 1 March 2000 , pp. 515-523(9)

Abstract:

Altered recombination patterns along non-disjoined chromosomes is the first molecular correlate identified for non-disjunction in humans. To understand better the factors related to this correlate, we have asked to what extent is recombination altered in an egg with a disomic chromosome: are patterns limited to the non-disjoined chromosome or do they extend to the entire cell? More specifically, we asked whether there is reduced recombination in the total genome of an egg with a non-disjoined chromosome 21 and no detectable recombination. We chose this subclass of non-disjoined chromosomes to enrich potentially for extremes in recombination. We found a statistically significant cell-wide reduction in the mean recombination rate in these eggs with non-disjoined chromosomes 21; no specific chromosomes were driving this effect. Most importantly, we found that this reduction was consistent with normal variation in recombination observed among eggs. Thus, given that recombination is a multifactorial trait, these data suggest that when the number of genome-wide recombination events is less than some threshold, specific chromosomes may be at an increased risk for non-disjunction. Further studies are required to confirm these results, to determine the importance of genetic and environmental factors that regulate recombination and to determine their impact on non-disjunction.

Document Type: Research article

Affiliations: 1: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA and 2: Marshfield Medical Research Foundation, 1000 North Oak Avenue, Marshfield, WI 54449, USA

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Genome-wide variation in recombination in female meiosis: a risk factor for non-disjunction of chromosome 21