Authors: Qiu, Yu Tong; van Loon, Joop J.A.; Takken, Willem; Meijerink, Jocelijn; Smid, Hans M.

Source: Chemical Senses, Volume 31, Number 9, November 2006 , pp. 845-863(19)

Publisher: Oxford University Press

Abstract:

Olfactory receptor neurons (ORNs) in the antenna of insects serve to encode odors in action potential activity conducted to the olfactory lobe of the deuterocerebrum. We performed an analysis of the electrophysiological responses of olfactory neurons in the antennae of the female malaria mosquito Anopheles gambiae s.s. and investigated the effect of blood feeding on responsiveness. Forty-four chemicals that are known to be present in human volatile emanations were used as odor stimuli. We identified 6 functional types of trichoid sensilla and 5 functional types of grooved-peg sensilla (GP) based on a hierarchical cluster analysis. Generalist ORNs, tuned to a broad range of odors, moderate specialist ORNs and 2 ORNs tuned to only one odor were identified in different sensilla types. Neurons in GP were tuned to more polar compounds including the important behavioral attractant ammonia and its synergist L-lactic acid, responses to which were found only in GP. Combinatorial coding is the most plausible principle operating in the olfactory system of this mosquito species. We document for the first time both up- and downregulation of ORN responsiveness after blood feeding. Modulation of host-seeking and oviposition behavior is associated with both qualitative and quantitative changes in the peripheral sensory system.

Keywords: electrophysiology; human odor; olfaction; ORN; receptor neuron; single-sensillum recording

Document Type: Research article

DOI: http://dx.doi.org/10.1093/chemse/bjl027

Publication date: 2006-11-01

More about this publication?

• Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal's coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.

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