NAT2 slow acetylator genotype is associated with increased risk of lung cancer among non-smoking Chinese women in Singapore
Authors: Lee E.J.D.1; Zhao B.1; Poh W-T.4; Teh M.2; Eng P.5; Wang Y-T.6; Tan W-C.3; Seow A.; Lee H-P.
Source: Carcinogenesis, Volume 20, Number 9, September 1999 , pp. 1877-1881(5)
Publisher: Oxford University Press
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Abstract:
Among non-smokers, the factors resulting in lung carcinogenesis are poorly understood. We conducted a hospital-based case-control analysis of 294 Chinese women, of whom 217 were non-smokers, to evaluate the role of polymorphic N-acetyltransferase (NAT2) as a susceptibility factor for the disease. The proportion of slow acetylator genotypes among non-smoking cases (n = 92) and controls (n = 125) was 38.0 and 24.0%, respectively [odds ratio (OR) 2.0, 95% confidence interval (CI) 1.1–3.7]. No effect of NAT2 genotype was seen among smokers. Among non-smokers, the effect was marked for adenocarcinomas (OR 2.1, 95% CI 1.1–4.0). As NAT2 activity is known to modify risk of arylamine-induced carcinogenesis, our results suggest that exposure to arylamines in the environment may play a role in risk of lung cancer among non-smokers.
Document Type: Original article
Affiliations: Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, 16 Medical Drive, Singapore, 117597, : 1: Department of Pharmacology, 2: Department of Pathology and 3: Department of Medicine, Faculty of Medicine, National University of Singapore, Lower Kent Ridge Road, Singapore, 119260, 4: Department of Pathology and 5: Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Outram Road, Singapore, 169608 and 6: Department of Respiratory Medicine, Tan Tock Seng Hospital, Moulmeri Road, Singapore 308433
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