MACiE: a database of enzyme reaction mechanisms

Authors: Holliday, Gemma L.; Bartlett, Gail J.; Almonacid, Daniel E.; O'Boyle, Noel M.; Murray-Rust, Peter; Thornton, Janet M.; Mitchell, John B. O.

Source: Bioinformatics, Volume 21, Number 23, 1 December 2005 , pp. 4315-4316(2)

Publisher: Oxford University Press

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Abstract:

Summary: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create a classification system which reflects the actual chemical mechanism (catalytic steps) of an enzyme reaction, not only the overall reaction.

Availability: http://www-mitchell.ch.cam.ac.uk/macie/

Contact: jbom1@cam.ac.uk

Keywords: Juvenile idiopathic arthritis; Disease activity; Measurement

Document Type: Research article

DOI: http://dx.doi.org/10.1093/bioinformatics/bti693

Publication date: 2005-12-01

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The leading journal in its field, Bioinformatics publishes the highest quality scientific papers and review articles of interest to academic and industrial researchers. Its main focus is on new developments in genome bioinformatics and computational biology. Two distinct sections within the journal - Discovery Notes and Application Notes- focus on shorter papers; the former reporting biologically interesting discoveries using computational methods, the latter exploring the applications used for experiments.