Vaccines against human enteric bacterial pathogens

Authors: Gordon Dougan1; Alan Huett1; Simon Clare1

Source: British Medical Bulletin, Volume 62, Number 1, July 2002 , pp. 113-123(11)

Publisher: Oxford University Press

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Abstract:

The development of vaccines against enteric bacterial pathogens presents a challenge because of the large number of pathogens capable of causing disease and the requirement to induce immunity that is effective in the gut. A new generation of enteric vaccines based either on live or non-living antigens delivered orally or by injection are reaching the clinic in the early phases of evaluation. However, considerable technical barriers have to be overcome before these vaccines reach the general population.

Document Type: Research article

Affiliations: 1: Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London, UK

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