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Brain provides researchers and clinicians with the finest original contributions in neurology. Leading studies in neurological science are balanced with practical clinical articles. Its citation rating is one of the highest for neurology journals, and it consistently publishes papers that become classics in the field. The Editorial Board reflects both the journal's truly international readership and wide coverage.

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Volume 135, Number 1, 9 January 2012

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A comment on impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations
pp. e197-e197(1)
Authors: Sturiale, Carmelo Lucio; Puca, Alfredo; Albanese, Alessio; Maira, Giulio; Colicchio, Gabriella

Reply: A comment on impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations
pp. e198-e198(1)
Authors: Fierstra, Jorn; Conklin, John; Krings, Timo; Slessarev, Marat; Han, Jay S.; Fisher, Joseph A.; TerBrugge, Karel; Wallace, M. Chris; Tymianski, Michael; Mikulis, David J.

Mutations of TSEN and CASK genes are prevalent in pontocerebellar hypoplasias type 2 and 4
pp. e199-e199(1)
Authors: Valayannopoulos, Vassili; Michot, Caroline; Rodriguez, Diana; Hubert, Laurence; Saillour, Yoann; Labrune, Philippe; de Laveaucoupet, Jocelyne; Brunelle, Francis; Amiel, Jeanne; Lyonnet, Stanislas; Enza-Razavi, Ferecht; Atti-Bitach, Tania; Lacombe, Didier; Bahi-Buisson, Nadia; Desguerre, Isabelle; Chelly, Jamel; Burglen, Lydie; Boddaert, Nathalie; de Lonlay, Pascale

Reply: Mutations of TSEN and CASK genes are prevalent in pontocerebellar hypoplasias type 2 and 4
pp. e200-e200(1)
Authors: Namavar, Yasmin; Barth, Peter G.; Baas, Frank; Poll-The, Bwee Tien

Cerebral microbleeds in familial Alzheimers disease
pp. e201-e201(1)
Authors: Ryan, Natalie S.; Bastos-Leite, Antnio J.; Rohrer, Jonathan D.; Werring, David J.; Fox, Nick C.; Rossor, Martin N.; Schott, Jonathan M.

Reply: Cerebral microbleeds in familial Alzheimers disease
pp. e202-e202(1)
Authors: van der Flier, Wiesje M.; Cordonnier, Charlotte

The impact of dementia prevalence on the utility of the AD8
pp. e203-e203(1)
Author: Christensen, Kathy J.

Reply: The impact of dementia prevalence on the utility of the AD8
pp. e204-e204(1)
Authors: Galvin, James E.; Morris, John C.

Editorial
pp. 1-3(3)
Author: Compston, Alastair

From The Archives
pp. 4-8(5)
Author: Compston, Alastair

Dysfunctional mitochondrial maintenance: what breaks the circle of life?
pp. 9-11(3)
Authors: Yu-Wai-Man, Patrick; Chinnery, Patrick F.

Assembly factors as a new class of disease genes for mitochondrial complex I deficiency: cause, pathology and treatment options
pp. 12-22(11)
Authors: Nouws, Jessica; Nijtmans, Leo G. J.; Smeitink, Jan A.; Vogel, Rutger O.

The MFN2 gene is responsible for mitochondrial DNA instability and optic atrophy plus phenotype
pp. 23-34(12)
Authors: Rouzier, Ccile; Bannwarth, Sylvie; Chaussenot, Annabelle; Chevrollier, Arnaud; Verschueren, Annie; Bonello-Palot, Nathalie; Fragaki, Konstantina; Cano, Aline; Pouget, Jean; Pellissier, Jean-Franois; Procaccio, Vincent; Chabrol, Brigitte; Paquis-Flucklinger, Vronique

Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy
pp. 35-52(18)
Authors: Bouaita, Aicha; Augustin, Sbastien; Lechauve, Christophe; Cwerman-Thibault, Hlne; Bnit, Paule; Simonutti, Manuel; Paques, Michel; Rustin, Pierre; Sahel, Jos-Alain; Corral-Debrinski, Marisol

Increased capillaries in mitochondrial myopathy: implications for the regulation of oxygen delivery
pp. 53-61(9)
Authors: Taivassalo, Tanja; Ayyad, Karen; Haller, Ronald G.

Sensory neuronopathy in patients harbouring recessive polymerase mutations
pp. 62-71(10)
Authors: Lax, Nichola Z.; Whittaker, Roger G.; Hepplewhite, Philippa D.; Reeve, Amy K.; Blakely, Emma L.; Jaros, Evelyn; Ince, Paul G.; Taylor, Robert W.; Fawcett, Peter R. W.; Turnbull, Doug M.

A rat model of CharcotMarieTooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients
pp. 72-87(16)
Authors: Fledrich, Robert; Schlotter-Weigel, Beate; Schnizer, Tuuli J.; Wichert, Sven P.; Stassart, Ruth M.; Meyer zu Hrste, Gerd; Klink, Axel; Weiss, Bernhard G.; Haag, Uwe; Walter, Maggie C.; Rautenstrauss, Bernd; Paulus, Walter; Rossner, Moritz J.; Sereda, Michael W.

Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for CharcotMarieTooth disease type 1X
pp. 88-104(17)
Authors: Groh, Janos; Weis, Joachim; Zieger, Hanna; Stanley, E. Richard; Heuer, Heike; Martini, Rudolf

Defective dentate nucleus GABA receptors in essential tremor
pp. 105-116(12)
Authors: Paris-Robidas, Sarah; Brochu, Elodie; Sintes, Marion; Emond, Vincent; Bousquet, Mlanie; Vandal, Milne; Pilote, Mireille; Tremblay, Cyntia; Di Paolo, Thrse; Rajput, Ali H.; Rajput, Alex; Calon, Frdric

Believing is perceiving: mismatch between self-report and actigraphy in psychogenic tremor
pp. 117-123(7)
Authors: Pares, Isabel; Saifee, Tabish A.; Kassavetis, Panagiotis; Kojovic, Maja; Rubio-Agusti, Ignacio; Rothwell, John C.; Bhatia, Kailash P.; Edwards, Mark J.

Dopaminergic neuroprotection of hormonal replacement therapy in young and aged menopausal rats: role of the brain angiotensin system
pp. 124-138(15)
Authors: Rodriguez-Perez, Ana I.; Valenzuela, Rita; Villar-Cheda, Begoa; Guerra, Maria J.; Labandeira-Garcia, Jose L.

Subthalamic nucleus stimulation reverses spinal motoneuron activity in parkinsonian patients
pp. 139-147(9)
Authors: Raoul, Sylvie; Roualdes, Vincent; Deligny, Cline; Leduc, Dominique; Lamy, Jean-Charles; Lackmy-Valle, Alexandra; N'Guyen, Jean-Paul; Damier, Philippe; Katz, Rose

Alpha oscillations in the pedunculopontine nucleus correlate with gait performance in parkinsonism
pp. 148-160(13)
Authors: Thevathasan, Wesley; Pogosyan, Alek; Hyam, Jonathan A.; Jenkinson, Ned; Foltynie, Tom; Limousin, Patricia; Bogdanovic, Marko; Zrinzo, Ludvic; Green, Alexander L.; Aziz, Tipu Z.; Brown, Peter

Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study
pp. 161-169(9)
Authors: Baba, Toru; Kikuchi, Akio; Hirayama, Kazumi; Nishio, Yoshiyuki; Hosokai, Yoshiyuki; Kanno, Shigenori; Hasegawa, Takafumi; Sugeno, Naoto; Konno, Masatoshi; Suzuki, Kyoko; Takahashi, Shoki; Fukuda, Hiroshi; Aoki, Masashi; Itoyama, Yasuto; Mori, Etsuro; Takeda, Atsushi

Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease
pp. 170-180(11)
Authors: Weintraub, Daniel; Dietz, Nicole; Duda, John E.; Wolk, David A.; Doshi, Jimit; Xie, Sharon X.; Davatzikos, Christos; Clark, Christopher M.; Siderowf, Andrew

Bloodbrain barrier P-glycoprotein function in Alzheimer's disease
pp. 181-189(9)
Authors: van Assema, Danille M. E.; Lubberink, Mark; Bauer, Martin; van der Flier, Wiesje M.; Schuit, Robert C.; Windhorst, Albert D.; Comans, Emile F. I.; Hoetjes, Nikie J.; Tolboom, Nelleke; Langer, Oliver; Mller, Markus; Scheltens, Philip; Lammertsma, Adriaan A.; van Berckel, Bart N. M.

Impairments of auditory scene analysis in Alzheimer's disease
pp. 190-200(11)
Authors: Goll, Johanna C.; Kim, Lois G.; Ridgway, Gerard R.; Hailstone, Julia C.; Lehmann, Manja; Buckley, Aisling H.; Crutch, Sebastian J.; Warren, Jason D.

Executive deficits are related to the inferior frontal junction in early dementia
pp. 201-215(15)
Authors: Schroeter, Matthias L.; Vogt, Barbara; Frisch, Stefan; Becker, Georg; Barthel, Henryk; Mueller, Karsten; Villringer, Arno; Sabri, Osama

Effect of growth hormone deficiency on brain structure, motor function and cognition
pp. 216-227(12)
Authors: Webb, Emma A.; O'Reilly, Michelle A.; Clayden, Jonathan D.; Seunarine, Kiran K.; Chong, Wui K.; Dale, Naomi; Salt, Alison; Clark, Chris A.; Dattani, Mehul T.

Theory of mind impairments in patients with semantic dementia
pp. 228-241(14)
Authors: Duval, Cline; Bejanin, Alexandre; Piolino, Pascale; Laisney, Mickael; de La Sayette, Vincent; Belliard, Serge; Eustache, Francis; Desgranges, Batrice

Semantic memory is impaired in patients with unilateral anterior temporal lobe resection for temporal lobe epilepsy
pp. 242-258(17)
Authors: Lambon Ralph, Matthew A.; Ehsan, Sheeba; Baker, Gus A.; Rogers, Timothy T.

Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
pp. 259-275(17)
Authors: Dreier, Jens P.; Major, Sebastian; Pannek, Heinz-Wolfgang; Woitzik, Johannes; Scheel, Michael; Wiesenthal, Dirk; Martus, Peter; Winkler, Maren K.L.; Hartings, Jed A.; Fabricius, Martin; Speckmann, Erwin-Josef; Gorji, Ali

Cortical activation changes underlying stimulation-induced behavioural gains in chronic stroke
pp. 276-284(9)
Authors: Stagg, Charlotte Jane; Bachtiar, Velicia; O'Shea, Jacinta; Allman, Claire; Bosnell, Rosemary Ann; Kischka, Udo; Matthews, Paul McMahan; Johansen-Berg, Heidi

The discovery of the pyramidal neurons: Vladimir Betz and a new era of neuroscience
pp. 285-300(16)
Authors: Kushchayev, Sergiy V.; Moskalenko, Vitaliy F.; Wiener, Philip C.; Tsymbaliuk, Vitaliy I.; Cherkasov, Viktor G.; Dzyavulska, Irina V.; Kovalchuk, Oleksander I.; Sonntag, Volker K. H.; Spetzler, Robert F.; Preul, Mark C.

Golgi: a life in science
pp. 301-303(3)
Author: Glickstein, Mitchell

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