Predicted effect compartment concentration of thiopental at loss of eyelash reflex

Authors: Lim T.A.; Inbasegaran K.

Source: BJA: British Journal of Anaesthesia, Volume 86, Number 3, 1 March 2001 , pp. 422-424(3)

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Abstract:

We derived the predicted effect compartment concentration of thiopental, at loss of the eyelash reflex, following three different injection regimens. Sixty patients were given thiopental for induction of anaesthesia. Twenty patients received multiple small boluses, 20 patients received a single bolus and 20 patients received an infusion. Computer simulation was then used to derive the effect compartment concentration. The median concentration was not significantly different between the three groups. EC₅₀, derived after combining all three groups was 11.3 µg ml^–1. The EC₀₅–EC₉₅ range was 6.9–18.3 µg ml^–1, suggesting wide inter-individual variation.

Br J Anaesth 2001; 86: 422–4

Keywords: Keywords:anaesthetics i.v., thiopental; pharmacokinetics, thiopental

Document Type: Original article

Affiliations: 1Anaesthesiology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. 2Department of Anaesthesiology and Intensive Care, Hospital Kuala Lumpur, Malaysia*Corresponding author: Anaesthesiology Unit, Universiti Putra Malaysia, Aras 8, Grand Seasons Avenue, Jalan Pahang, Kuala Lumpur, Malaysia

Publication date: 2001-03-01

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Founded in 1923, one year after the first anaesthetic journal was published by the International Anaesthesia Research Society, the British Journal of Anaesthesia remains the oldest and largest independent journal of anaesthesia. It became the journal of The College of Anaesthetists in 1990. The College was granted a Royal Charter in 1992. Although there are educational links between the BJA and the College, the journal retains editorial independence.