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Among the important scientific developments of the 20th century is the explosive growth in statistical reasoning and methods for application to studies of human health. Examples include developments in likelihood methods for inference, epidemiologic statistics, clinical trials, survival analysis, and statistical genetics. Substantive problems in public health and biomedical research have fueled the development of statistical methods, which in turn have improved our ability to draw valid inferences from data. The objective of Biostatistics is to advance statistical science and its application to problems of human health and disease, with the ultimate goal of advancing the public's health.

Publisher: Oxford University Press

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Volume 13, Number 1, January 2012

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Letter to the editor
pp. 1-3(3)
Author: Nikoloulopoulos, Aristidis K.

A survival analysis approach to modeling human fecundity
pp. 4-17(14)
Authors: Sundaram, Rajeshwari; McLain, Alexander C.; Buck Louis, Germaine M.

Checking semiparametric transformation models with censored data
pp. 18-31(14)
Authors: Chen, Li; Lin, D. Y.; Zeng, Donglin

A joint latent variable model approach to item reduction and validation
pp. 48-60(13)
Authors: Halberstadt, Steffanie M.; Schmitz, Kathryn H.; Sammel, Mary D.

Mixed model analysis of censored longitudinal data with flexible random-effects density
pp. 61-73(13)
Authors: Vock, David M.; Davidian, Marie; Tsiatis, Anastasios A.; Muir, Andrew J.

Evaluating prognostic accuracy of biomarkers in nested casecontrol studies
pp. 89-100(12)
Authors: Cai, Tianxi; Zheng, Yingye

A Bayesian hierarchical model for identifying epitopes in peptide microarray data
pp. 101-112(12)
Authors: Arima, Serena; Lin, Jing; Pecora, Valentina; Tardella, Luca

Significance analysis and statistical dissection of variably methylated regions
pp. 166-178(13)
Authors: Jaffe, Andrew E.; Feinberg, Andrew P.; Irizarry, Rafael A.; Leek, Jeffrey T.

Relative risk regression: reliable and flexible methods for log-binomial models
pp. 179-192(14)
Authors: Marschner, Ian C.; Gillett, Alexandra C.

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