Estimating Dermal Exposure to Jet Fuel (Naphthalene) Using Adhesive Tape Strip Samples
Source: Annals of Occupational Hygiene, Volume 48, Number 2, March 2004 , pp. 139-146(8)
Publisher: Oxford University Press
Abstract:A simple, non-invasive dermal sampling technique was developed and tested on 22 human volunteers under laboratory conditions to estimate acute dermal exposure to jet fuel (JP-8). Two sites on the ventral surface of each forearm were exposed to 25 µl of JP-8 and the non-viable epidermis (stratum corneum) was sequentially tape-stripped using an adhesive tape. Samples were extracted with acetone and analyzed by gas chromatography/mass spectrometry. Analysis of the first tape strips indicated that JP-8 was rapidly removed from the stratum corneum over the 20 min study period. On average, after 5 min of exposure the first two tape strips removed 69.8% of the applied dose. The amount recovered with two tape strips decreased over time to a recovery of 0.9% 20 min after exposure. By fitting a mixed-effects linear regression model to the tape strip data, we were able to estimate accurately the amount of JP-8 initially applied. This study indicates that naphthalene has a short retention time in the human stratum corneum and that the tape stripping method, if used within 20 min of the initial exposure, can be used to measure reliably the amount of naphthalene initially in the stratum corneum due to a single exposure to jet fuel. We are currently investigating the applicability of the developed mixed-effects linear regression model to estimate acute JP-8 exposure levels based upon naphthalene measurements from tape strips collected from occupationally exposed workers.
Document Type: Research Article
Affiliations: 1: Department of Environmental Sciences and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, CB 7431, Rosenau Hall, Chapel Hill, NC 27599-7431, USA; 2: Department of Biostatistics, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Publication date: 2004-03-01
- Annals of Occupational Hygiene is one of the world's top research journals on hazards and risks to health resulting from work. The journal is particularly interested in recognition, quantification, management and control of risk. It includes papers on basic mechanisms, human aspects and technology, and on environmental risks to humans when these are work-related. Published papers originate from all over the world, with about 60% from continental Europe and North America.