Authors: KALOUSOVÁ MARTA¹; ZIMA TOMÁ²; POPOV PETR³; PAEK PAVEL⁴; BRAUN MARTIN⁴; SOUKUPOVÁ JIINA²; PELINKOVÁ KVTA²; KIENTSCH-ENGEL ROSEMARIE⁵

Source: Alcohol and Alcoholism, Volume 39, Number 4, July 2004 , pp. 316-320(5)

Publisher: Oxford University Press

Abstract:

Aims: The aim of our study was to determine serum levels of advanced glycation end-products (AGE) in patients with chronic alcohol misuse and to examine their relationship to markers of nutrition and inflammation. Methods: The study group consisted of 23 heavy alcohol drinkers treated for chronic alcohol misuse and 22 healthy controls. Studied parameters included AGE (fluorescence, CML – carboxymethyllysine and pentosidine), lipids, glucose, albumin, leptin, prealbumin, C-reactive protein (CRP) and pregnancy-associated plasma protein A (PAPP-A). Results: AGE fluorescence was significantly higher in chronic alcoholic patients than in healthy subjects (4.3 ± 0.7 × 10³ vs 3.7 ± 0.5 × 10³ AU/g protein, P < 0.005), while CML was only slightly but not significantly elevated (569.1 ± 106.6 vs 545.5 ± 85.8 g/l) and pentosidine levels did not differ (105.4 ± 29 vs 102.2 ± 23 nmol/l). In alcoholics, AGE correlate significantly negatively with leptin (r = -0.46, P < 0.05) and pentosidine with prealbumin (r = -0.43, P < 0.05), otherwise there was no relationship between AGE and other biochemical parameters (glucose, cholesterol, albumin, CRP, PAPP-A). Conclusion: Our findings suggest a more complex relationship among advanced glycation, oxidative stress and metabolism of ethanol and their link to nutrition and nutrition-associated parameters. AGE as a result of oxidative stress might be similarly linked to increased cardiovascular risk of heavy alcohol drinkers, as are malnutrition and inflammation; however, further studies are needed to confirm this hypothesis.

Document Type: Research article

DOI: http://dx.doi.org/10.1093/alcalc/agh058

Affiliations: 1: Institute of Medical Biochemistry, 2: Institute of Clinical Chemistry and Laboratory Diagnostics, 3: Department for Treatment of Addictions and 4: Institute of Rheumatology, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic and 5: Roche Diagnostics, Penzberg, Germany

Publication date: 2004-07-01

More about this publication?

• Alcohol and Alcoholism publishes papers on biomedical, psychological and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contribution are not of a largely speculative or philosophical nature. Alcohol and Alcoholism is the official journal of the Medical Council on Alcohol.

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