Authors: Andreas Fellgiebel¹; Thomas Siessmeier²; Georg Winterer¹; Hartmut Lüddens¹; Klaus Mann¹; Lutz G Schmidt¹; Peter Bartenstein²

Source: Alcohol and Alcoholism, Volume 39, Number 2, March 2004 , pp. 150-153(4)

Publisher: Oxford University Press

Abstract:

Aims: To investigate a possible relationship between cerebellar glucose metabolism and recovery from ataxia in the first months of acute Wernicke–Korsakoff syndrome. Methods: Two cases of alcoholic Wernicke–Korsakoff syndrome were followed up with the clinical status and cerebral glucose metabolism over a 4- and 9-month period. Results: Initially both patients showed severe ataxia and elevated cerebellar glucose metabolism that decreased corresponding to the restitution of stance and gait. Conclusion: Increased cerebellar glucose metabolism at the onset of the illness may reflect the reorganization process of disturbed motor skills and may indicate cerebellar plasticity.

Document Type: Research article

DOI: http://dx.doi.org/10.1093/alcalc/agh016

Affiliations: 1: Psychiatry and 2: Nuclear Medicine, University Hospital of Mainz, Mainz, Germany

Publication date: 2004-03-01

More about this publication?

• Alcohol and Alcoholism publishes papers on biomedical, psychological and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contribution are not of a largely speculative or philosophical nature. Alcohol and Alcoholism is the official journal of the Medical Council on Alcohol.

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