Alcohol Intake After Serotonin Transporter Inactivation in Mice

Authors: S. Kelaï¹; F. Aïssi²; K.P. Lesch³; C. Cohen-Salmon²; M. Hamon¹; L. Lanfumey¹

Source: Alcohol and Alcoholism, Volume 38, Number 4, July 2003 , pp. 386-389(4)

Buy & download fulltext article:

Price: $42.29 plus tax (Refund Policy)

Abstract:

Knock-out mice lacking the serotonin transporter [5-hydroxytryptamine transporter (5-HTT)] were used to assess the influence of 5-HT re-uptake on ethanol consumption. Under a free-choice paradigm, alcohol intake was lower in mutant than in wild-type mice, and pharmacological blockade of 5-HTT by fluoxetine reduced alcohol intake in wild-type mice only. These data confirm the inhibitory effect of 5-HTT inactivation on ethanol intake.

Document Type: Rapid communication

Affiliations: 1: INSERM U288, Neuropsychopharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l’Hôpital, 75634 Paris Cedex 13, 2: CNRS UMR-7593, Personnalité et conduites adaptatives, IFR (70) des Neurosciences, CHU Pitié-Salpêtrière, 75013 Paris, France and 3: Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, 97080 Würzburg, Germany

Publication date: 2003-07-01

More about this publication?

Alcohol and Alcoholism publishes papers on biomedical, psychological and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contribution are not of a largely speculative or philosophical nature. Alcohol and Alcoholism is the official journal of the Medical Council on Alcohol.