Post-translational regulation of FOXO

Authors: Xie, Qi; Chen, Jing; Yuan, Zengqiang

Source: Acta Biochimica et Biophysica Sinica, Volume 44, Number 11, November 2012 , pp. 897-901(5)

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Abstract:

The Forkhead box O (FOXO) family transcription factors play critical roles in a series of cellular processes, including the cell cycle, cell death, metabolism, and oxidative stress resistance. FOXO proteins are subject to several post-translational modifications, which are closely related to their activity. In this paper, we review the post-translational modifications of FOXOs and their biological functions.

Keywords: FOXO; phosphorylation; acetylation; ubiquitination; methylation

Document Type: Research article

DOI: http://dx.doi.org/10.1093/abbs/gms067

Publication date: 2012-11-01