Phoenix rising: gene therapy makes a comeback

Author: Limberis, Maria P.

Source: Acta Biochimica et Biophysica Sinica, 1 August 2012, vol. 44, no. 8, pp. 632-640(9)

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Abstract:

Despite the first application of gene therapy in 1990, gene therapy has until recently failed to meet the huge expectations set forth by researchers, clinicians, and patients, thus dampening enthusiasm for an imminent cure for many life-threatening genetic diseases. Nonetheless, in recent years we have witnessed a strong comeback for gene therapy, with clinical successes in young and adult subjects suffering from inherited forms of blindness or from X-linked severe combined immunodeficiency disease. In this review, various gene therapy vectors progressing into clinical development and pivotal advances in gene therapy trials will be discussed.

Keywords: gene therapy; genetic disease; genetic vectors

Document Type: Research Article

DOI: http://dx.doi.org/10.1093/abbs/gms036

Publication date: August 1, 2012

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