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An update on the epidemiology of aspirin-exacerbated respiratory disease

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Background:

Aspirin-exacerbated respiratory disease (AERD) is a disorder of nasal polyposis, asthma, and hypersensitivity respiratory reactions when on systemic cyclooxygenase 1 blockade.

Methods:

AERD warrants specific evaluation as an endotype of asthma and chronic sinus disease due to unique therapeutic opportunities. Currently, aspirin therapy is uniquely beneficial as an anti-inflammatory therapy in AERD, with multiple additional therapies currently in early to late clinical studies, which might also show exceptional benefit in AERD.

Results:

Yet, given the lack of a simple diagnostic test, opportunities to identify patients with AERD are still frequently neglected.

Conclusion:

Identifying the prevalence and population characteristics necessary to determine appropriate candidates in whom to perform diagnostic aspirin challenge remains critically important and was the purpose of this article.
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Keywords: AERD; Aspirin-exacerbated respiratory disease; NSAID exacerbated respiratory disease; Samter syndrome; aspirin intolerance; epidemiology; prevalence

Document Type: Research Article

Publication date: 2017-09-01

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