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Interleukin-18 gene polymorphisms in Egyptian patients with allergic diseases

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Abstract:

Background:

Allergic diseases, such as allergic rhinitis (AR) and atopic dermatitis (AD), affect a large proportion of people worldwide. Both have environmental and genetic predisposing factors. Single nucleotide polymorphisms (SNPs) in interleukin (IL)-18, may play a direct role in the disease pathogenesis. This study was designed to investigate the association of the IL-18 gene SNPs (−137 G/C [rs187238], and −140 C/G [rs360721]) with AR and AD, as well as their relations to the diseases' severity.

Methods:

Seventy-five individuals were enrolled in the study including, 25 AD children, 25 AR patients, and 25 unrelated healthy adult volunteers who served as controls. Genotyping was performed by polymerase chain reaction and restriction fragment length polymorphism analysis.

Results:

AR and AD patients showed no significant differences in the genotype distribution and allele frequencies of −137 G/C and −140 C/G SNPs when compared independently with the control group. However, the −140 GG genotype and the −140 G allele were more often associated with severe AD compared with mild and moderate phenotypes (p = 0.01 and 0.001, respectively; odds ratios [ORs], 14.25 [95% CI, 1.48‐143.2] and 16 [95% CI, 2.8‐90.46], respectively). Moreover, the −137 G allele was associated with moderate/severe AR (p = 0.019; OR, 6.1 [95% CI, 1.34‐28.1]).

Conclusion:

This preliminary study indicates that the studied polymorphisms do not confer susceptibility to allergy in Egyptian patients but may be related to the disease phenotype. However, the role of IL-18 in allergy may be too complex to be reflected in a simple association study.

Keywords: Allergic rhinitis; SNP; atopic dermatitis; genotype; interleukin-18

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/ajra.2012.26.3806

Affiliations: Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Publication date: September 1, 2012

More about this publication?
  • The American Journal of Rhinology & Allergy, is a peer reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    Previously published as American Journal of Rhinology, the journal is indexed in Thomson Reuters Web of Science and Science Citation Index, plus the National Library of Medicine's PubMed service.
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