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Immunomodulatory treatments for aspirin exacerbated respiratory disease

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Background:

Aspirin triad is a subclass of chronic sinusitis characterized by nasal polyposis, nonallergic induced asthma, and aspirin sensitivity. Also known as Samter's triad or aspirin-exacerbated respiratory disease, aspirin triad commonly affects the adult population and is seldom found in pediatric patients.

Methods:

This rhinosinusitis has multiple layers of pathological process, but the ultimate predicament is caused by cysteinyl leukotrienes (cysLTs).

Results:

Pharmacotherapies include oral steroid, lipoxygenase inhibitor, and cysLT receptor inhibitor drugs, which can provide some relief for these patients.

Conclusion:

Immunomodulation via aspirin desensitization is considered when pharmacotherapy has failed. When aspirin triad is unmanageable with medical treatment alone, endoscopic sinus surgery with polypectomy can alleviate the patient's symptoms, allowing for a better response to postoperative medical management such as topical medication as well as delivery of topical medications.
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Keywords: Aspirin desensitization; Samter's Triad; aspirin exacerbated respiratory disease; aspirin triad; chronic sinusitis; immunomodulation; leukotriene; rhinosinusitis; treatment

Document Type: Research Article

Affiliations: Department of Otolaryngology and Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia, USA

Publication date: 01 March 2012

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