Skip to main content

Spirometric abnormalities in patients with allergic rhinitis: Indicator of an “asthma march”?

Buy Article:

$49.50 plus tax (Refund Policy)



Allergic rhinitis (AR) may precede and promote the onset of asthma. However, few studies addressed this issue mainly concerning bronchial physiological parameters. The aim of this study was to assess forced expiratory flow at 25‐75% (FEF25‐75), forced expiratory volume at 1 second (FEV1), and response to bronchodilation test in a large group of AR patients.


Sixteen hundred five adult AR patients were evaluated. Clinical examination, assessment of nasal obstruction perception by visual analog scale, spirometry, and bronchodilation test were performed in all patients.


There were 8.4% of patients with abnormal FEV1 values, 24.7% had impaired FEF25‐75, and 66.1% had reversibility with bronchodilation. A trend of spirometric impairment seems to exist in these patients. Age, gender, and duration of rhinitis may be risk factors for these findings. Different grades of bronchial impairment seem to exist.


This study highlights the close link between upper and lower airways and suggests the possible existence of a progression from AR toward asthma, such as an “asthma march.” Therefore, asthma should be suspected and carefully investigated in AR patients.

Keywords: Allergic rhinitis; FEF25‐75; FEV1; asthma; bronchodilation

Document Type: Research Article


Affiliations: Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy

Publication date: September 1, 2011

More about this publication?
  • The American Journal of Rhinology & Allergy, is a peer reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    Previously published as American Journal of Rhinology, the journal is indexed in Thomson Reuters Web of Science and Science Citation Index, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Information for Advertisers
  • Reprint Requests
  • ingentaconnect is not responsible for the content or availability of external websites

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more