Skip to main content

The nose as a target organ in the diagnosis of severe aspirin-exacerbated respiratory disease

Buy Article:

$44.50 plus tax (Refund Policy)

Abstract:

Background:

The nasal provocation test (NPT) with lysine aspirin is a useful tool in the diagnosis of aspirin-exacerbated respiratory disease (AERD), previously reffered to as Samter′s disease. The aim of the present study focuses on methodological interventions to show the usefulness of the NPT with lysine aspirin in differentiating AERD patients from aspirin-tolerant asthma (ATA) patients to improve the diagnostic efficacy and minimize the risk for adverse reactions compared with the gold standard.

Methods:

Thirty AERD patients comprised the active study group while the control group consisted of 25 ATA patients. A combination of objective nasal aerodynamic response (i.e., nasal inspiratory flow and nasal inspiratory resistance) was evaluated by active anterior rhinomanometry and the subjective clinical nasal and extranasal symptoms (including forced expiratory volume) were monitored throughout the challenge.

Results:

Fifty-five NPTs were successfully completed: sensitivity, 87%; specificity, 100%; positive predictive value, 100%; negative predictive value, 86%; global efficacy, 92.72%. No severe adverse reactions were recorded.

Conclusion:

The present NPT with lysine aspirin proved to be a safe, efficient, and a timesaving method in the diagnosis of patients with AERD, even in those with severe rhinitis‐rhinosinusitis and/or recurrent nasal polyposis.

Keywords: Aspirin-exacerbated respiratory disease; NSAID intolerance; Samter′s disease; diagnosis; lysine aspirin; nasal aerodynamics; nasal provocation test; rhinitis; rhinomanometry; rhinosinusitis

Document Type: Research Article

DOI: https://doi.org/10.2500/ajra.2011.25.3591

Affiliations: Servicio de Alergia, Hospital Universitario N.Sra. La Candelaria, Santa Cruz de Tenerife, Spain

Publication date: 2011-05-01

More about this publication?
  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more