Matrix metalloproteinase-9 promoter gene polymorphism (−1562C>T) in nasal polyposis

Authors: Erbek, Selim S.; Yurtcu, Erkan; Erbek, Seyra; Sahin, Feride I.

Source: American Journal of Rhinology & Allergy, Volume 23, Number 6, November/December 2009 , pp. 568-570(3)

Publisher: OceanSide Publications, Inc

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Abstract:

Background:

Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP.

Methods:

A prospective and case-control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (−1562C>T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.

Results:

The frequency of −1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy.

Conclusion:

In this study, MMP-9 −1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP.

Keywords: Chronic inflammation; genotype; matrix metalloproteinase-9; nasal polyposis; paranasal sinus; polymorphism; susceptibility

Document Type: Research article

DOI: http://dx.doi.org/10.2500/ajra.2009.23.3371

Affiliations: 1: Department of Otolaryngology, Baskent University, Faculty of Medicine, Ankara, Turkey. selimerbek@gmail.com

Publication date: 2009-11-01

More about this publication?

The American Journal of Rhinology & Allergy, is a peer reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials and review articles.

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Previously published as American Journal of Rhinology, the journal is indexed in Thomson Reuters Web of Science and Science Citation Index, plus the National Library of Medicine's PubMed service.
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Matrix metalloproteinase-9 promoter gene polymorphism (−1562C>T) in nasal polyposis

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