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Matrix metalloproteinase-9 promoter gene polymorphism (−1562C>T) in nasal polyposis

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Background:

Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP.

Methods:

A prospective and case-control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (−1562C>T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.

Results:

The frequency of −1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy.

Conclusion:

In this study, MMP-9 −1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP.
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Keywords: Chronic inflammation; genotype; matrix metalloproteinase-9; nasal polyposis; paranasal sinus; polymorphism; susceptibility

Document Type: Research Article

Affiliations: Department of Otolaryngology, Baskent University, Faculty of Medicine, Ankara, Turkey. [email protected]

Publication date: 01 November 2009

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