IngentaConnect No significant role for angiogenesis in nasal polyposis

Authors: Ahmed, Shahzada K.¹; Williams, James L.¹; Drake-Lee, Adrian²; Egginton, Stuart¹

Source: American Journal of Rhinology, Volume 22, Number 1, January-February 2008 , pp. 24-28(5)

Publisher: OceanSide Publications, Inc

Abstract:

Background: Nasal polyposis is a common disease of which little is currently known. Recent studies have shown up-regulation of several proangiogenic factors. The aim of this study was to assess and quantify how much angiogenesis occurs in nasal polyps and therefore whether angiogenesis is involved in the etiology of polyposis.

Methods: Biopsy specimens of polyp tissue and inferior turbinate (IT) were taken from patients undergoing polypectomy and compared with IT samples from control patients. Five patients were used per study group. Biopsy specimens were either stained with a fluorescent lectin for confocal microscopy or snap frozen and sectioned for histology for the examination of multiple measures of angiogenesis.

Results: No significant differences in capillary density, capillary-associated proliferation, capillary surface density, or capillary volume density were seen between the three study groups, and the regression of surface density versus volume density described a linear relationship. Polyp samples showed increases in capillary diameter and interstitial proliferation.

Conclusion: These results show no active angiogenesis occurring in the polyp or changes in capillary bed architecture, although capillaries seem more edematous in the polyp. As the capillary supply increases in line with the physiological needs of the growing polyp, we conclude that angiogenesis is not a driving force in the etiology of nasal polyposis.

Keywords: Angiogenesis; capillary proliferation index; capillary topology; etiology; immunohistochemistry; nasal mucosa; nasal polyposis; polyps; vascularity

Document Type: Research article

DOI: 10.2500/ajr.2008.22.3124

Affiliations: 1: From the Angiogenesis Research Group, Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom, and 2: Department of Otolaryngology, Head and Neck Surgery, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom

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