Expression and distribution of aquaporin-1 in nasal polyps: Does it have any significance in edema formation?

Authors: Altuntaş, Ali; Yılmaz, Mustafa Deniz; Aktepe, Fatma; Kahveci, Orhan Kemal; Derekoy, Sefa; Dilek, Hüsniye; Serteser, Mustafa

Source: American Journal of Rhinology, Volume 20, Number 1, January-February 2006 , pp. 128-131(4)

Publisher: OceanSide Publications, Inc

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Abstract:

Background: The aim of this study was to investigate the expression of Aquaporin 1 (AQP1) and AQP4 in polyp tissue.

Methods: Nasal polyps were obtained from 34 patients with nasal polyposis during endoscopic sinus surgery. Bullous middle turbinates with normal-appearing mucosa of 10 patients were used as controls. Expression of AQP1 and AQP4 water channels were determined by immunohistochemical methods.

Results: AQP1 has been found to be expressed in fibroblasts located in polyp tissue, especially in the subepithelial area, periphery of seromucous glands, and endothelial cells of venules.

Conclusion: We have established a high expression of AQP1 water channels in nasal polyp tissue and have suggested two mechanisms to explain this finding. Increased AQP1 expression may be a cause or a consequence of edema formation. Thus, additional studies are needed to elucidate the true mechanism underlying this relationship.

Document Type: Research article

Publication date: 2006-01-01

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Now published as American Journal of Rhinology & Allergy, the journal is indexed in Thomson Reuters Web of Science and Science Citation Index, plus the National Library of Medicine's PubMed service.

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