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Atopic dermatitis treatment: Current state of the art and emerging therapies

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Background:

Atopic dermatitis (AD) can be debilitating and often requires the use of combination topical and systemic therapy to achieve adequate disease control.

Methods:

A non-systematic review was performed of current state of the art and emerging therapies for AD.

Results:

There are a number of topical agents approved by the U.S. Food and Drug Administration (FDA) for the treatment of AD and multiple nonapproved systemic agents that are used off label for the treatment of AD. All of these have limitations of efficacy and/or safety, which leads to a number of unmet disease-treatment needs. Recent insight has identified a number of novel pathways as treatment targets for AD, including the T-helper type 2 cytokines, interleukins (IL) 4, IL-13, IL-33, phosphodiesterase E 4, and Janus kinase signaling. Dupilumab is a monoclonal antibody that inhibits interleukin 4 and 13 signaling and was recently approved by the FDA for the treatment of moderate-severe AD in adults.

Discussion:

There are a number of current treatment approaches and emerging therapies for AD.
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Keywords: Atopic dermatitis; Janus Kinase (JAK); azathioprine; crisaborole; cyclosporine; dupilumab; glucocorticoids; immunosuppressants; interleukin 13 (IL-13); interleukin 4 (IL-4); lebrikizumab; methotrexate; nemolizumab; phosphodiesterase E 4 (PDE-4); tofacitinib; topical calcineurin inhibitors; topical corticosteroids; tralokinumab; treatment

Document Type: Research Article

Publication date: 2017-07-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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