Irreversible airway obstruction in asthma: What we lose, we lose early
Asthma, a syndrome manifested by airway inflammation and obstruction, globally contributes significantly to morbidity and mortality. Although current evidence identifies risk factors that evoke asthma, critical questions concerning susceptibility factors that induce severe persistent
disease remain unclear. Early onset of asthma decreases lung function that may be unrecognized until later in adulthood when patients experience dyspnea on exertion and attenuated quality of life. This review highlights current evidence in predicting the onset of asthma and identifying those
patients at greatest risk for severe persistent disease.
Keywords: Airway inflammation; RSV; RV infections; airway pathophysiology; asthma development; atopy; bronchial epithelium; bronchial smooth muscle; early onset asthma; irreversible airway obstruction; wheezing
Document Type: Research Article
Affiliations: Translational Medicine, Respiratory, Inflammation, and Autoimmunity Group, MedImmune, LLC, Gaithersburg, Maryland, USA
Publication date: 01 March 2014
This article was made available online on 07 November 2013 as a Fast Track article with title: "Irreversible airway obstruction in asthma: What we lose, we lose early".
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