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A 9-year-old boy with chronic urticaria and progressive spondyloarthritis

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A 9-year-old African American boy presented with chronic urticaria and progressive spondyloarthritis. Laboratory tests were abnormal for persistently positive antinuclear antibodies and undetectable total hemolytic complement (CH50) despite normal levels of complement C2, C3, and C4. Ultimately, further testing revealed an underlying deficiency in the immune system that may be associated with autoimmune disease and thus have a bearing on the patient's urticaria and spondyloarthritis. This is a unique presentation of a rare disease and underscores the importance of evaluating for systemic disease in the workup of chronic urticaria.
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Keywords: Autoimmune diseases; complement component C8; complement deficiency; humans; immunologic deficiency syndromes; juvenile chronic arthritis; juvenile idiopathic arthritis; spondyloarthritis; systemic lupus erythematosus; urticaria

Document Type: Research Article

Affiliations: Children’s Foundation Research Institute at Le Bonheur Children’s Hospital, University of Tennessee Health Science Center, Memphis, Tennessee, USA

Publication date: 2013-01-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

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    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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