A 9-year-old boy with chronic urticaria and progressive spondyloarthritis
Authors: Park, Dai; Brown, Monica L.; Densen, Peter; Myers, Linda K.; Lew, D. Betty
Source: Allergy and Asthma Proceedings, Volume 34, Number 1, January/February 2013 , pp. 103-107(5)
Publisher: OceanSide Publications, Inc
Abstract:A 9-year-old African American boy presented with chronic urticaria and progressive spondyloarthritis. Laboratory tests were abnormal for persistently positive antinuclear antibodies and undetectable total hemolytic complement (CH50) despite normal levels of complement C2, C3, and C4. Ultimately, further testing revealed an underlying deficiency in the immune system that may be associated with autoimmune disease and thus have a bearing on the patient's urticaria and spondyloarthritis. This is a unique presentation of a rare disease and underscores the importance of evaluating for systemic disease in the workup of chronic urticaria.
Keywords: Autoimmune diseases; complement component C8; complement deficiency; humans; immunologic deficiency syndromes; juvenile chronic arthritis; juvenile idiopathic arthritis; spondyloarthritis; systemic lupus erythematosus; urticaria
Document Type: Research Article
Affiliations: Children’s Foundation Research Institute at Le Bonheur Children’s Hospital, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Publication date: 2013-01-01
- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.
Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
Articles marked "F" offer free full text for personal noncommercial use only.
The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
- Editorial Board
- Information for Authors
- Submit a Paper
- Information for Advertisers
- Reprint Requests
- ingentaconnect is not responsible for the content or availability of external websites