A study of IgE sensitization and skin response to histamine in Asian-Pacific American adults

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Abstract:

Allergic disorders and skin response to histamine have been noted to vary in different ethnicities. We investigated IgE-mediated allergic sensitization and skin response to histamine in Asian Pacific Americans (APAs), black and Hispanic Americans, and white adults. A retrospective questionnaire-based study was performed of 2222 adults presenting at a New York City allergy referral center from 1994 to 2003. Questionnaire data included sex, age, and ethnicity and personal and family history of atopic disorders. Skin-prick test (SPT) data included saline and histamine controls and response to a standardized panel of 10 aeroallergens. APA patients had a lower odds of asthma (adjusted odds ratio [aOR], 0.68; 95% confidence interval [CI], 0.52‐0.89; p = 0.005) and/or animal allergies (aOR, 0.64; 95% CI, 0.50‐0.82; p = 0.0003). Histamine response was not significantly different in APA (aOR, 0.90; 95% CI, 0.73‐1.12; p = 0.36) or Hispanic Americans (aOR, 1.03; 95% CI, 0.85‐1.24; p = 0.76), but was higher in black Americans (aOR, 2.32; 95% CI, 1.67‐3.21; p < 0.0001). APA had higher odds of a positive SPT to trees (aOR, 1.49; 95% CI, 1.16‐1.91; p = 0.002), grasses (aOR, 1.32; 95% CI, 1.05‐1.43; p = 0.02), feathers (aOR, 1.65; 95% CI, 1.31‐2.09; p < 0.0001), and cockroaches (aOR, 1.37; 95% CI, 1.10‐1.62; p = 0.005). Moreover, APA had a higher total number of positive SPTs when compared with white patients (5.5 ± 3.2 versus 4.9 ± 3.3; aOR, 1.34; 95% CI, 1.10‐1.62 p = 0.004). APA adults in our patient population had more IgE sensitizations but not an increased skin response to histamine. In contrast, black Americans had increased skin response to histamine.

Keywords: Aeroallergen; Asian; IgE-mediated sensitization; animal allergies; asthma; atopy; drug allergies; eczema; ethnicity; food allergies; hay fever; histamine; race; season; sex; skin-prick

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2012.33.3575

Affiliations: Beth Israel Medical Center, Division of Allergy/Clinical Immunology, New York, New York, USA

Publication date: July 1, 2012

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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