A forced expiratory flow at 25‐75% value <65% of predicted should be considered abnormal: A real-world, cross-sectional study

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Abstract:

Forced expiratory volume in 1 second (FEV1) is considered an important parameter for asthma diagnosis and follow-up. However, it has been proposed that forced expiratory flow at 25‐75% (FEF25‐75) could be more sensitive than FEV1 to detect slight airways obstruction. In this regard, a cutoff FEF25‐75 value has been recently established in a group of asthmatic children: FEF25‐75 < 65% of predicted has been considered impaired. However, the considered population was specifically selected. Therefore, the aim of the present study was to confirm an FEF25‐75 cutoff value in a large cohort of asthmatic children. Seven hundred allergic children (493 male subjects; median age, 11 years) with controlled and partly controlled asthma were evaluated by performing spirometry and skin-prick tests. Three hundred thirteen (44.7%) patients had FEF25‐75% values of <65% of predicted. Two predictors were significantly associated with impaired FEF25‐75 values: (i) sensitization to perennial allergens (adjusted odds ratio [ORAdj], 3.4) and (ii) FEV1 ≤ 86% of predicted (ORAdj, 3.8). This study, conducted in real life, could suggest that FEF25‐75 value of <65% of predicted may be considered abnormal.

Keywords: Allergic asthma; FEF25‐75; FEV1; children; cutoff; spirometry

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2012.33.3524

Affiliations: Istituto di Ricovero e Cura a Carattere Scientifico–Azienda Ospedaliera Universitaria San Martino, Genoa, Italy

Publication date: January 1, 2012

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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