Angioedema: Differential diagnosis and treatment
Conditions causing angioedema can be loosely classified as those with underlying C1-inhibitor deficiency or dysfunction and those that do not. Determining the root cause of symptoms and ruling out conditions that masquerade as angioedema help clinicians plan appropriate management. The various etiologies of angioedema have overlapping symptoms that can complicate the diagnosis. An awareness of features unique to a specific cause of angioedema will aid in the differential diagnosis. A thorough history may reveal a family history of episodic swelling, bouts of swelling associated with medication use, or swelling associated with certain foods or environmental allergens. Similarly, a history of symptom onset later in life is more common in acquired angioedema. The presence of urticaria suggests an allergic component. Treatment strategies have been devised for all forms of angioedema, although specific therapeutic targets may be unknown. Several medications directed at the underlying cause of symptoms in hereditary angioedema have been recently approved for use in the United States. Clinical symptoms, differential diagnosis, and management strategies for angioedema are reviewed in this article.
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Document Type: Research Article
Affiliations: Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, USA
Publication date: 2011-09-01
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- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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