@article {Magen:2011:1088-5412:460,
title = "Clinical and laboratory features of antihistamine-resistant chronic idiopathic urticaria",
journal = "Allergy and Asthma Proceedings",
parent_itemid = "infobike://ocean/aap",
publishercode ="ocean",
year = "2011",
volume = "32",
number = "6",
publication date ="2011-11-01T00:00:00",
pages = "460-466",
itemtype = "ARTICLE",
issn = "1088-5412",
eissn = "1539-6304",
url = "https://www.ingentaconnect.com/content/ocean/aap/2011/00000032/00000006/art00015",
doi = "doi:10.2500/aap.2011.32.3483",
keyword = "resistant, idiopathic, CRP, spontaneous, MPV, C3, urticaria, inflammation, chronic, Antihistamine",
author = "Magen, Eli and Mishal, Joseph and Zeldin, Yuri and Schlesinger, Menachem",
abstract = "Chronic idiopathic (spontaneous) urticaria (CIU) is sometimes resistant to the conventional and high doses of antihistamines (AHs). This study compares the clinical and laboratory characteristics of AH responsive and AH-resistant CIU subjects. Clinical and laboratory data were retrospectively
collected from 385 CIU patients. Urticaria activity score (UAS), concomitant angioedema, dermatographism, positive autologous serum skin (ASST), and laboratory data were collected. The control group consisted of 44 sex- and age-matched healthy individuals. Two hundred forty-five CIU patients
controlled with AH medications were included in the CIU group. Forty-six patients failed to show clinical improvement during 8 weeks of treatment with fourfold AH doses and were included in the resistant CIU (R-CIU) group. The R-CIU group was characterized with a higher incidence (58.7%) of
angioedema than the CIU group (28.5%; p < 0.001), more cases concomitant physical urticaria (23.9% in R-CIU versus 12.2% in CIU; p = 0.014), more positive ASST (73.9% in R-CIU versus 45.4% in CIU; p < 0.001), and higher baseline UAS (5.28 \textpm 0.81 in R-CIU versus 3.32 \textpm 1.25
in CIU; 3 versus 0.16 \textpm 0.13 cell/mm3; p < 0.001), higher mean platelet volume (10.87 \textpm 2.21 femtoliter (fl) versus 8.65 \textpm 1.74 fl; p < 0.001), higher
levels of C-reactive protein (8.62 \textpm 3.91 mg/L versus 2.49 \textpm 1.34 mg/L; <0.001), and higher levels of serum C3 (1.66 \textpm 0.36 g/L versus 1.19 \textpm 0.35 g/L; p < 0.001. R-CIU is a clinically more severe disease with laboratory features of low-grade inflammation
and platelet activation.",
}