Selective cyclooxygenase-2 inhibitor cross-reactivity in aspirin-exacerbated respiratory disease
Authors: Umemoto, Junichi; Tsurikisawa, Naomi; Nogi, Shinichi; Iwata, Kanako; Oshikata, Chiyako; Tatsuno, Sayaka; Tanimoto, Hidenori; Sekiya, Kiyoshi; Tsuburai, Takahiro; Mitomi, Hiroyuki; Akiyama, Kazuo
Source: Allergy and Asthma Proceedings, Volume 32, Number 3, May/June 2011 , pp. 259-261(3)
Publisher: OceanSide Publications, Inc
Abstract:Aspirin-induced asthma (AIA) is a severe and difficult-to-treat allergic disease in which acute asthma attacks are induced by nonsteroidal anti-inflammatory drugs. Patients with AIA rarely experience asthma attacks when taking celecoxib, a specific inhibitor of cyclooxygenase (COX) 2. A 33-year-old woman had a severe asthma attack with hypoxia and lost consciousness after oral provocation testing with 15 mg of aspirin and also with 50 mg of celecoxib. After 2 months of treatment with 10 mg/day of oral prednisolone, 1600 μg/day of inhaled fluticasone propionate, montelukast as a leukotriene receptor antagonist (LTRA), and long-term beta-agonist, we again challenged her with a provocation test with up to 200 mg of celecoxib; this time there were neither allergic symptoms nor decrease in forced expiratory volume in 1 second. Patients with severe or poorly controlled asthma may experience asthma attacks even if using selective COX-2 inhibitors. However, treatment with steroids and an LTRAs may inhibit asthma attacks induced by celecoxib.
Document Type: Research Article
Publication date: May 1, 2011
- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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