Bronchial hyperreactivity in patients with allergic rhinitis: Forced expiratory flow between 25 and 75% of vital capacity might be a predictive factor

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Allergic rhinitis (AR) is considered a strong risk factor for the onset of asthma. Bronchial hyperreactivity (BHR) may be present in patients with AR. Forced expiratory flow between 25 and 75% of vital capacity (FEF25‐75) may be impaired in AR patients. The aim of this study was to evaluate the presence of BHR in a large group of patients with AR and whether FEF25‐75 might be related to BHR. Four thousand seven hundred eighty-one patients with AR were enrolled. Clinical examination, skin-prick test, spirometry, and methacholine challenge were performed in all patients. Fourteen percent of patients had severe BHR and 25.3% had mild BHR. Patients with low FEF25‐75 values (such as ≤65% of predicted) had severe BHR more frequently than patients with normal FEF25‐75 values (p < 0.001). In addition, low FEF25‐75 values constitute a relevant predictive factor (OR = 12.9) for severe BHR. This study shows that a relevant percentage of AR patients had BHR, and impaired FEF25‐75 values might predict it. Therefore, BHR should be suspected in AR patients with low FEF25‐75 values.

Keywords: Allergic rhinitis; BHR; FEF25‐75

Document Type: Research Article


Affiliations: Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy

Publication date: March 1, 2011

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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