Authors: Kaliner, Michael A.; Oppenheimer, John; Farrar, Judith R.

Source: Allergy and Asthma Proceedings, Volume 31, Number 2, March/April 2010 , pp. 112-119(8)

Publisher: OceanSide Publications, Inc

Abstract:

Olopatadine is a tricyclic compound with antihistaminic, mast cell-stabilizing, and anti-inflammatory properties. In the United States olopatadine is approved as a b.i.d. ophthalmic solution, Patanol (Alcon Laboratories, Inc., Fort Worth, TX) to treat all signs and symptoms of allergic conjunctivitis and as a q.d. formulation, Pataday (Alcon Laboratories, Inc.), to treat itching associated with allergic conjunctivitis. A nasal spray, Patanase (Alcon Laboratories, Inc.), was approved in 2008 for treatment of the symptoms of seasonal allergic rhinitis. The available data on olopatadine was assessed with regard to future uses through a comprehensive literature review and a Roundtable Discussion held at the 2009 meeting of the American Academy of Allergy Asthma and Immunology. The unique mechanisms of action of olopatadine still under study include mast cell stabilization, potent H₁-anthistaminic activity, and anti-inflammatory effects. Data support consideration of nasal olopatadine for as-needed use for episodic symptoms of allergic rhinitis, for treatment of nonallergic rhinitis, and for use in combination with topical steroids for patients with moderate-to-severe allergy symptoms.

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Supplementary Data: 1 item

Keywords: Allergic conjunctivitis; allergic rhinitis; antihistamine; mast cell stabilizer; nasal allergy; nasal antihistamine; ocular allergy; olopatadine

Document Type: Research article

DOI: http://dx.doi.org/10.2500/aap.2010.31.3317

Affiliations: 1: Institute for Asthma and Allergy, Chevy Chase, Maryland, USA. makaliner@aol.com

Publication date: 2010-03-01

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• Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
  
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